Following a DNA customized diet resulted in 76% more weight loss in a recent study by a major university.
Individuals with the IRS1 rs2943641 CC genotype, the risk allele, lost 76% more weight with a diet appropriate for their genotype compared to individuals with no risk alleles (TT), who used the same diet which was not appropriate for their genotype.
This is just one example of a gene variant (SNP) that GenoVive uses to determine the best diet for you based on your DNA. The GenoVive Weight Management DNA Test uses 15 different SNPs with documented impact on weight loss as indicated by a minimum of 2 human intervention clinical trials per SNP.
Here are a few more studies:
- In a diet and exercise behavioral intervention, individuals with the Arg64 (C) variant were more resistant to weight loss than those with the Trp (T) variant. 48% with the risk variant (C) lost weight compared to 69% of the participants without the variant. (Difficulty In Losing Weight By Behavioral Intervention For Women With Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene– K Shiwaku, K Shimono)
- In a three-year dietary and exercise intervention which studied the Pro12Ala polymorphism in the PPARg2 gene, Ala12Ala individuals showed more lost weight than those with the risk genotype Pro12. This trial further demonstrated that individuals with the high risk Pro12 allele are more sensitive to the fat in diet and resistant to weight loss. (Association of the Pro12Ala Polymorphism in the PPARg2 Gene With Three-Year Incidence of Type 2 Diabetes and Body Weight Change - V Lindi and J Tuomilehto)
- In a meta-analysis of 237,434 samples, Individuals with the FTO risk variant (A) have an increased risk of obesity (1.23X/allele) and an increased risk of being overweight (1.15X/allele). BUT this effect is attenuated by physical activities. (Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk – T Kilpeläinen and R Loos)
- Following a six-month diet and exercise intervention, individuals with the Thr54 (A) variant showed significantly greater waist circumference than those with the Ala (G)variant. These individuals have a lower resting metabolic rate (RMR), higher resistance to reducing visceral white adipose tissue and are inclined to an earlier onset of obesity. (Thr54 Allele of the FABP2 Gene Affects Resting Metabolic Rate and Visceral Obesity - Y Takakura and T Yoshida)
* Studies done in controlled environments. Your individual results may vary.